There are two key gameplay elements: Driving around the city as fast as you can and destroying buildings with your in-car entertainment (ice) system.
To navigate you have the aid of a map, descriptions of the next target and a way-pointer which will always point towards targets. The waypointer's length shortens as you get closer.
Each car has a different driving style - try them all. Maybe you'll enjoy drifting and handbrake around corners or perhaps you'll just want the machine with the smallest turning circle.
When destroying buildings you may be able to destroy two at once. This will save time and boost your score.